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Walter Unger, M.D.,F.R.C., P(C), F.A.C.P
Hair Transplant Specialist
620 Park Avenue
New York, NY 10021
Tel. 212.249.9393

99 Yorkville Ave., Suite 214
Toronto, ON Canada M5R 3K5
Tel. 416.944.9393
THE PRINCIPLE
Hair Transplantation depends on the now well-established principle that transplanted hair follicles (roots moved from their original location to another area) will behave as they did in their original site. For example, even in the most advanced cases of common Male Pattern Baldness (MPB), a horseshoe-shaped fringe of hair persists. Hair follicles moved from this hair-bearing fringe (the donor area) to a bald or balding area on the same patient's scalp (the recipient area), will take root and grow. Continuing hair growth in such transplants has been observed since 1958, and it is believed that a majority of the hairs (see below) will continue to grow for the individual's lifetime. Many other types of hair loss, in addition to ordinary MPB, can be helped by this procedure. These include Female Pattern Hair Loss (FPHL); scarring from prior injuries or surgery; and a number of diseases that sometimes cause hair loss.
 Article by Dr. Unger
Hair transplanting: An important but often forgotten treatment for female pattern hair loss
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THE PROCEDURE
  1. At the beginning of each session, the patient is given a mild tranquilizer (Valium or Versed) either orally or intravenously. This minimizes anxiety, reduces discomfort, and helps to prevent or decrease any side effects that might be caused by the local anesthetic.
  2. Hair in the donor area is clipped to a 2-mm length in a single zone that is less than 12 mm (1/2") wide, and 10- 25 cm (4-10") long. If the hair in the hair-bearing fringe has been left 1½-2" long, the hair above the donor site completely camouflages it immediately after the procedure.
  3. The donor area and the recipient area are anesthetized using a very small gauge needle that is about the size of an acupuncture needle to inject a local anesthetic. To reduce any stinging sensation, in addition to using a small gauge needle, we prepare and use an anesthetic solution that is at an almost neutral pH, instead of "stock" anesthetics which are stored in an acidic form. (The acidity is the main cause of the stinging one usually feels with anesthetic injections). Anesthetizing the areas is the only uncomfortable part of the session and although it may be hard to believe, many patients have told us that the above technique usually causes less discomfort than a visit to their dentist.
  4. After the anesthetic has taken effect, a scalpel is used to cut narrow (usually 8-10 mm [1/3 – 2/3 inch] ) "strips" or "ellipses" of hair-bearing scalp from the donor areas. A similar method can also be used to remove scar(s) from preceding scalp surgery or injury. This tissue is then divided into a variety of graft sizes. In subsequent transplant sessions, the scar from the preceding session(s) is excised as part of the new donor strip; it is therefore rare that more than one scar will be produced, regardless of the number of sessions that are undertaken.
  5. Many types of grafts are now used in the recipient area. In general, the smaller the size of the graft used, the less noticeable treatment will be postoperatively and in between sessions, i.e. the more natural the result will appear after a single session. However, larger grafts are occasionally utilized if, a) high density is the ultimate goal, b) the patient is judged to have an unusually good long-term donor/recipient area ratio and c) the individual is prepared to undergo at least two sessions in the same area.

The following is a description of the types of grafts we employ:

a) "Follicular Units" (FU), also called "micrografts": Although approximately 15-20% of scalp hairs emerge from the scalp as single hairs, the majority of them emerge in small groupings of 2 to 5 hairs (Fig. 1). These "follicular groups" or "follicular units" are obtained by slicing the donor tissue, using a stereoscopic microscope, into the naturally occurring single hairs and small groupings. FUs are placed into tiny holes made with an ordinary hypodermic needle or small blade. Because transplanting exclusively with FUs creates a natural-looking growth of hair, even after only one session in a bald area (or an area destined to become bald), Follicular Unit Transplanting (FUT) is used to create the hairline zone in 100% of patients and for all recipient areas in 99% of our patients (Figs. 2-7). FUs are also used in front of any larger grafts (grafts that contain more than one FU) that may also occasionally be used, or to fill in any hairless gaps between previously transplanted FUs, or larger grafts (see below). If a typical FUT session of 1500 FU to 2500 FU is being carried out, we feel that a physician ideally should limit himself/herself to only a single surgery that day—assuming that he/she is excising the donor tissue and making all the recipient site incisions. Such large procedures begin at 7:30 a.m. and usually last until 3:30 to 5:30 p.m. We therefore believe that limiting oneself to only one surgery that day is optimal for the physician and the patient.

b) Donor tissue may also be microscopically sliced into narrow sections each of which contains two to three FUs (lined up one behind the other like a row of soldiers). These are placed into incisions made with varying sizes of small blades. Such "micro-slit" grafts may be used behind a hairline zone composed exclusively of FUs, and in combination with FUs in a 3/4 - 1" wide zone in front of still larger grafts (as described below), to produce a natural-looking hairline with gradually increasing hair density.

The more persisting original hair in the recipient area, the finer the texture of your hair, the less contrast between the color of your hair and skin, and the more frizz or curl in your hair, the less the difference there is between the apparent naturalness of FUs and micro-slit grafts (or for that matter, even larger grafts) (Figs. 8-9).

c) "Slot grafts" are similar to "micro-slit" grafts in that they contain FUs lined up behind each other like a row of "soldiers" but in the case of slot grafts, there are two side-by-side rows rather than a single row of "soldiers" and each slot graft includes twice as many FUs as are present in a "micro-slit" graft of comparable length. These "fat" micro-slit grafts are placed into a linear slot made by a special "slot" punch. They can produce almost the same hair density as round grafts, (Figs. 9-10) but because they have a linear shape, they are usually less easy to detect between a series of sessions than round grafts.

d) "Round" grafts are actually square grafts that contain an average of 8 to 20 or more hairs, but that are inserted into round holes made in the recipient area with a round "punch" that has a diameter of 1.5 to 3.5 mm. The holes are placed approximately one graft apart, in a "checkerboard" fashion, to leave a surrounding blood supply. Four sessions can solidly fill any area. "Round" grafts are the most efficient way to produce very dense coverage. After four sessions, one can approximate the normal donor area hair density of approximately 220 or more hairs per cm2— as opposed to a maximum density of approximately 150 hairs per cm2 after multiple sessions of exclusive FUs (Fig. 10). However, if round grafts are used, they are always placed behind a hairline zone composed of one or more of the smaller graft types described earlier. Because most patients do not have a good enough long-term donor/recipient area ratio, or because they may (or may not) look "pluggy" between transplanting sessions, "round" grafts are currently used in less than 1% of our patients.

In general, FUs and micro-slit grafts produce more natural-looking results than an equivalent amount of donor tissue transplanted as slot grafts or round grafts. However, because no bald skin is actually removed (hair is only added), and because FUs can never be transplanted as close together as they exist naturally in donor tissue, FUs or micro-slit grafts cannot ultimately produce as high a hair density as slot and round grafts. On the other hand, FUs can produce a very good hair density and, as mentioned earlier, extraordinarily natural-looking results in a single session in an area that is bald or destined to become bald. Thus FUT also allows you to use up less of your limited supply of donor tissue in any one area, leaving more donor tissue "in the bank" for use in other areas that you have or might develop in the future. Put differently, you are not obligated to do more than one session in any area in order to produce naturalness—although a minority of patients ultimately decides to do that in order to produce maximum hair density.

Each case must be considered on an individual basis. There are a number of factors, which influence the decision as to which type of grafts will be used and where they will be placed; these include the texture and color of hair, hair density, the ultimate size of the donor area, the ultimate size of the site to be transplanted, and the patient's goals. In some individuals a combination of two or more of the graft types will be used but as noted earlier, in nearly all patients we now use FUs exclusively because FUT has been enormously improved since approximately 2000. During a consultation you will be shown photos of what you can expect from each grafting option. Despite claims to the contrary, no one type of graft will provide "the best of all worlds" for all patients.


6. Grafts are held in place by coagulated blood. To keep them secure and properly oriented, a turban-like bandage is usually applied after the operation and left in place overnight. The following day, the bandage is removed and the area is cleansed. If you are having the front portion of your scalp transplanted, and if there is no more than the average amount of bleeding during surgery, and you are willing to remain in the office for 30 minutes after the procedure is completed, you can go home without a bandage. Most patients seem to prefer the security of an overnight bandage. Perhaps more importantly, every scientific study on wound healing, of which we are aware, has revealed better and faster healing if a wound is covered for the first 12 to 24 hours. Whether you have a bandage or not, you should still return the next day for follow-up cleansing, hair washing, and a check-up.

NUMBER OF TRANSPLANT PROCEDURES NEEDED

The balding scalp should be conceptualized as being composed of three areas: a "frontal" area that extends from the hairline to a line drawn more or less perpendicularly from the ears; a "mid-scalp" area that extends from the frontal area as far back as a point at which the top of the scalp changes from a more or less horizontal orientation to a more or less vertical orientation, and a "crown" or "vertex" area that extends from the mid-scalp area to the borders of the hair-bearing fringe at the back of the head (Fig. 12). Each of these areas is usually treated separately, so that three sessions will be required to transplant all three areas in a man with an average-sized bald area. In men with smaller than average-sized bald areas, two sessions may cover all three areas, while in men who have or might develop larger than average-sized bald areas, four or more sessions may be necessary to transplant the entire bald area (and that many sessions may not be available from the donor area). Fortunately, transplanting just the frontal and mid-scalp areas produces the appearance of hair from frontal and side views and this often can be accomplished with only two sessions. (Many men naturally keep their frontal and mid-scalp hair while losing only the crown hair, so there is nothing unnatural about a man who has only a bald crown.) (Figs. 5 and 13). In addition to transplanting the clearly thinning or bald areas, we also like to concomitantly treat any adjacent areas that still contain some hair, but that on wetting the hair, appear on close inspection to be destined to eventually lose that hair. By treating these evolving areas of hair loss at the same time as the more easily seen areas of loss, we hope to minimize the need to constantly chase an enlarging area of MPB with additional sessions (Figs. 13-14).

While the frontal area can be completed with a single session, if only FUs are being used, the same area will usually need two to three sessions to produce adequate naturalness if FUs and micro-slit grafts or slot grafts are being used, and as many as three to three and one-half sessions if round grafts are also being employed. As discussed before, these larger types of grafts can produce more hair density than sessions of exclusive FUs, but once grafts containing more than a single FU are used, at least two sessions will be necessary in that area to produce sufficient natural-looking results. As also noted before, the finer your hair texture, the curlier or frizzier your hair is, and the less contrast between the color of your hair and skin, the fewer the number of sessions that will be required to create natural-looking results.

Transplant sessions may be done as far apart as the patient wishes; however, they are not done in the same area without at least a four-month interval between the first two sessions, and an interval of at least six months between the following sessions. In fact, we nearly always use a six-month or longer interval between all sessions in order for patients to appreciate a reasonable amount of hair growth from a prior session before undergoing another one. While the typical session done in our office will result in the transplantation of 1500-2500 FU (3450-5750 hairs) or its equivalent, the number of grafts that should be transplanted at one session, and the frequency of transplant sessions depend on the size of the graft utilized and the characteristics of each individual's hair texture, caliber, wave, color, and density. More importantly, the size of the session depends on the patient's hair density, scalp laxity, and the circumference of the head. We will do the largest session that we feel can prudently be done, keeping in mind that the blood supply in the recipient area also limits the size of session which can be expected to consistently produce good growth.

It is becoming more common for patients to have one or two "early" transplanting sessions before hair loss has reached an advanced stage. The benefit of these "early" sessions is threefold: a) the remaining hair provides natural camouflage for the initial session—not only for the immediate post-surgical period but also for what might otherwise be some noticeability of grafts that are larger than an FU. (As long as additional sessions are done in pace with the loss of the original hair, grafts containing more than one FU can be no more noticeable than a single follicular unit—without very close inspection), b) the transplanted hair (once it has grown) will persist and provides additional coverage for any later sessions and, c) because of a) and b), sessions can be spaced farther apart, thus spreading the inconvenience and cost over a longer period of time.

In 10% to 20% of male patients, there may be some "shock loss" or mild thinning involving the pre-existing hair of the recipient area within the first two to three weeks after a transplant. In women, the incidence is unfortunately closer to 40% to 50%. This thinning (if it occurs) typically consists of the loss of 1–3 of every 10 hairs and is ALWAYS temporary; the hair will regrow at the same time as the transplanted hair begins to sprout or often earlier.


WHAT TO EXPECT AFTER EACH SESSION

A crust or "scab" will form over each graft shortly after the procedure (Fig. 18) and will remain attached for several to 14 days. The smaller the graft, the smaller the "scab" and the shorter this period will be. The FU sites lose their scabs within 4 to 7 days, while larger sites may retain their scabs for up to 14 days. When the area is completely healed, the crusts will separate from the scalp and fall off leaving a clean, slightly pinkish area to indicate the site of each graft (Fig. 15). Although these crusts are present during the one- to two-week healing period, many patients can camouflage them by combing the adjacent hair over the transplanted site (Fig. 16). If a hairpiece is normally worn, it may be used after the first week, keeping in mind that it should be worn as little as possible until all of the crusts or "scabs" are gone. The hairs in the transplanted grafts are shed between the second and eighth week after the procedure. Sometimes they fall out attached to the separating crusts; often they persist longer. Rarely, some of the transplanted follicles do not shed their hair at all, but continue to grow immediately after the procedure. With these exceptions, the grafts are usually bare for a period of 10 to 14 weeks after the operation, during which time the follicles recuperate and begin to produce new hair. A new generation of hair is usually visible at the surface of the scalp by the 12th week after transplanting, but this may occur slightly earlier, or up to eight weeks later in a few patients. These hairs grow at the same rate as they did in their original location (which is usually 1/2 inch per month). FUs commonly show regrowth two to four weeks earlier than larger types of grafts.

When a large area is transplanted, swelling of the forehead frequently occurs. While this swelling is usually mild and lasts only two to four days, it occasionally can be severe enough to cause a large amount of puffiness around the eyes and approximately one out of 50 patients has swelling bad enough to cause "black eyes". Generally, the swelling begins two to three days after the procedure and is most noticeable after the first session. With subsequent treatments, it usually occurs in a milder form or not at all. In view of this, if possible, it is advisable to schedule a holiday to coincide with the first session. The swelling is ALWAYS temporary and has no harmful effect on the healing grafts. An intramuscular injection of a cortisone-type drug is usually given at the time of the operation to help minimize swelling.

Contrary to what many patients have been told, the scalp (hairy or bald) has an excellent blood supply. A certain amount of bleeding during the transplant procedure is expected and is simply controlled by applying pressure. The donor area is stitched closed to produce better scars and to minimize bleeding. The stitches are normally removed seven to ten days later.

The nurses will wash your hair the day after surgery. You may gently shampoo on the second day after transplanting.

Patients from out of town are required to stay in town overnight after the transplant procedure, so that any bandage can be removed and the areas of surgery can be properly cleaned. They should not drive home themselves on the day of surgery because of the lingering effects of medications. Ingrown hairs are occasionally a temporary problem, beginning 8 to 12 weeks after surgery, especially when FUs and micro-slit grafts are used, and especially if the hair tends to be naturally curly. It is easily controlled, does not cause any permanent damage, and does not occur in a majority of patients.

A temporary decrease in scalp sensitivity is always noted after transplanting because nerves are cut as donor tissue is taken and recipient sites are prepared. Usually this will correct itself completely in 6 to 18 months as the nerves regenerate. Rarely, there may be increased sensitivity in a small area that can take more than 18 months before it disappears, or permanent decreased sensitivity in a small area.


FINAL RESULTS

It is impossible to predict precisely how many hairs will appear in any given graft but usually, at least 95% of them will survive transplanting. Not uncommonly, more hairs will grow than were planted because some were in an invisible "resting phase" when they were originally counted. After more than 30,000 hair transplant sessions, we have never encountered a patient who failed to grow enough hair to produce a substantial cosmetic improvement.

Within one to six months, the skin surface of the grafts has usually blended in perfectly with the surrounding scalp. In some patients, however, grafts that contain more than one FU may be a shade lighter in color until they are "aged" by sun exposure. The grafts are usually level with the surrounding scalp, but a few may be slightly elevated in less than 0.1% of patients. Such grafts can be flattened down with an electric needle without interfering with hair growth. A small number of grafts, rarely, may also be slightly depressed. Surrounding skin can be cauterized to correct this or the graft can be replaced with another one, while the original graft can be re-utilized elsewhere in the recipient area.

The final appearance is that of "early thinning", which is not meant to imply "thin" hair, but rather to convey the idea that you cannot expect to look like you did when you were a teenager.

As one ages, the rim hair from which the grafts were taken gradually becomes less dense. Thus, transplanted areas will also thin somewhat with the passage of time. However, they will never go bald again. In addition, as the hair goes grey with aging, it will look thicker, so any decreased hair density may or may not be noticeable. Because of this gradual thinning effect, you may want to transplant the area a little thicker to begin with, or alternately, you may want to conserve some grafts for use in 15 to 20 years, for example.

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